Discussion
G protein-coupled receptors act by
Answer: B
Correct answer: activating a G protein that relays the signal
Binding of the ligand changes the receptor’s conformation so that it acts on an associated G protein, causing it to exchange GDP for GTP and dissociate. The activated subunit then acts on an effector such as adenylate cyclase or phospholipase C. The family is enormous - several hundred receptors in humans and the target of a large share of all prescribed drugs.
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