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If a receptor activates 100 G proteins and each leads to 1,000 second messenger molecules, how many messengers result from one receptor?

  • A.1,000
  • B.100,000
  • C.1,100
  • D.10,000

Answer: B

Multiplying 100 by 1,000 gives 100,000, which shows how a very small signal produces a very large internal response. Adding the two numbers instead is the usual error. Amplification is multiplicative at every stage of a cascade.

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