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Protein phosphatases are important in signalling because they

  • A.reverse phosphorylation and switch signals off
  • B.add further phosphate groups to proteins
  • C.carry the signal into the cell nucleus
  • D.produce cyclic AMP from adenosine triphosphate

Answer: A

A pathway that could only be switched on would stay on permanently, so termination matters as much as activation. Many diseases arise from a signal that fails to be turned off. Constitutively active signalling proteins are common in tumours.

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