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Cholera toxin causes severe diarrhoea by locking a G protein in its

  • A.phosphorylated state, so it cannot bind GTP
  • B.membrane, so it cannot reach its target enzyme
  • C.active state, so cyclic AMP is made continuously
  • D.inactive state, so no signal can be transmitted

Answer: C

The unregulated rise in cyclic AMP drives chloride and water out of the intestinal cells. It is a clear demonstration of what happens when a signal cannot be switched off. Rehydration therapy treats the consequence rather than the cause.

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