Discussion
State whether the following is true or false.
An agonist mimics the natural signal while an antagonist blocks it.
Answer: C
Correct answer: True
An agonist binds the receptor and produces the same conformational change as the natural ligand, so it triggers the response - morphine at the opioid receptor. An antagonist binds without activating and so occupies the site, preventing the natural ligand from acting - a beta blocker at the adrenergic receptor. Both depend on fitting the same binding site, and they differ only in what happens after binding.
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