Discussion
Signalling by direct contact between membrane-bound molecules on two cells is important in
Answer: B
Correct answer: immune recognition and development
Contact-dependent signalling requires the two cells to touch, so it is used where the identity of the particular neighbour matters. A T cell inspecting an antigen-presenting cell and the Notch-Delta interaction that decides which of two adjacent cells adopts which fate are the two classic cases - in both, the signal must be addressed to one specific cell and no other.
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