Discussion
Rous sarcoma virus, which induces the formation of sarcomas in chickens. Which of the following is the product of oncogene V-src ?
Answer: B
The product of v-src is a tyrosine kinase.
The src gene of Rous sarcoma virus was the first oncogene discovered. Its product, pp60v-src, is a non-receptor protein kinase that adds phosphate groups to tyrosine residues of target proteins. In the viral form it is permanently active, so it keeps growth signals switched on and transforms the cell.
It is not a growth factor such as EGF (the sis oncogene encodes a growth factor, PDGF). Tyrosinase is the enzyme of melanin synthesis, which has nothing to do with oncogenes, and serine kinases such as Raf phosphorylate serine and threonine, not tyrosine.
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