Discussion
Which one of the following pairs execute their functions by binding with cytoplasmic receptors ?
Answer: D
The pair that acts through cytoplasmic receptors is estrogen and progesterone.
Both are lipid-soluble steroid hormones. They cross the plasma membrane and bind intracellular receptors of the nuclear receptor family, found in the cytoplasm or nucleus. The hormone-receptor complex binds hormone response elements in DNA and changes gene transcription.
Each wrong pair contains a hormone that cannot cross the membrane and so uses a cell-surface receptor. Noradrenaline acts on G-protein coupled adrenergic receptors, growth hormone on a cytokine-type receptor linked to JAK2, and GABA on GABA-A ion channels and GABA-B receptors.
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