Discussion
Assertion (A): Some antibiotics inhibit bacterial protein synthesis without harming human cells.
Reason (R): Bacterial and eukaryotic ribosomes differ in size and structure.
Answer: A
Correct answer: Both A and R are true, and R is the correct explanation of A
Both are true and the reason is precisely why the drugs work. Bacterial ribosomes are 70S, built from 30S and 50S subunits; eukaryotic cytoplasmic ribosomes are 80S, from 40S and 60S. Tetracyclines, aminoglycosides and macrolides bind the bacterial subunits and not the human ones, which is what gives them their selective toxicity. Mitochondrial ribosomes are 70S, which is where some of these drugs’ side effects come from.
No comment is present. Be the first to comment.
Loading…
Post your comment
Please log in or register to post a comment.
Examination Categories
- SSC Exams
- Banking Exams
- Teaching Exams
- Civil Services Exams
- Railways Exams
- Engineering Recruitment Exams
- Defence Exams
- State Government Exams
- Police Exams
- Insurance Exams
- Nursing Exams
- Other Government Exams
- NRA CET
- PG Entrance Exams
- Campus Placement
- MBA Entrance Exams
- CUET and UG Entrance
- Judiciary Exams
- Regulatory Body Exams
- Software Development