Discussion
Down's syndrome is caused due to aberration in :
Answer: C
Down's syndrome is caused by an aberration in chromosome 21.
Most cases are trisomy 21, three copies of chromosome 21, usually from non-disjunction in the mother's meiosis; a few arise from a Robertsonian translocation carrying extra chromosome 21 material, or from mosaicism. The features include intellectual disability, a flat face and upward-slanting eyes, a single palmar crease and heart defects.
No viable syndrome involves trisomy of chromosome 2. Chromosome 20 is not the cause, and X-chromosome aneuploidies give Turner (XO) or Klinefelter (XXY) syndrome.
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