Discussion
Toxin A involved in pseudomembranous colitis is a type of _______________
Answer: B
Correct answer: enterotoxin
Clostridioides difficile produces two toxins. Toxin A is an enterotoxin, damaging the mucosa and causing fluid secretion and inflammation; toxin B is a cytotoxin, far more potent against cultured cells and the basis of the classical cell culture assay. Both glucosylate Rho GTPases, disrupting the actin cytoskeleton, and together they produce the pseudomembranes of the colitis that follows disturbance of the normal flora by antibiotics.
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