Discussion
Which of the following inactivates IgA antibodies?
Answer: B
Correct answer: Diphthin
Diphthin is an IgA protease produced by Corynebacterium diphtheriae; by cleaving secretory IgA it disables the principal antibody defence of the respiratory mucosa and helps the organism establish itself there. Cord factor is a mycobacterial glycolipid responsible for serpentine growth and granuloma formation, neuraminidase promotes spread through mucus, and K antigens are capsular antigens that resist phagocytosis - none of them acting on IgA.
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