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Regarding gas gangrene one of the following is correct:

  • A.It is due to Clostridium botulinum infection
  • B.Clostridial species are gram-negative anaerobes forming spores
  • C.The clinical features are due to the release of protein endotoxin
  • D.Gas is invariably present in the muscle compartments

Answer: D

Correct answer: Gas is invariably present in the muscle compartments

Gas in the muscle compartments, detectable as crepitus or on radiograph, is the defining feature that names the disease and is produced by the saccharolytic fermentation of the clostridia. The other statements are all wrong: gas gangrene is caused by C. perfringens and other clostridia, not C. botulinum; clostridia are Gram-positive spore formers; and the clinical features are due to exotoxins, chiefly alpha toxin, endotoxin being a feature of Gram-negative organisms.

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