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Regarding Clostridium perfringens gas gangrene, all are true, except:

  • A.Commonest cause of gas gangrene
  • B.Nagler’s reaction positive
  • C.Most common toxin is hyaluronidase
  • D.Food poisoning strains of Clostridium perfringens produce heat resistant spores

Answer: C

Correct answer: Most common toxin is hyaluronidase

This is the exception. The principal toxin of C. perfringens is the alpha toxin, a lecithinase that lyses cell membranes and is the main lethal and necrotising factor. Hyaluronidase is the mu toxin, one of the minor spreading factors. The other three statements are true: C. perfringens is the commonest cause of gas gangrene, it is Nagler positive, and its food poisoning strains form heat-resistant spores.

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