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True regarding pseudomembranous colitis are all except:

  • A.It is caused by Clostridium difficile
  • B.The organism is a normal commensal of gut
  • C.It is due to the production of phospholipase A
  • D.It is treated by vancomycin

Answer: C

Correct answer: It is due to the production of phospholipase A

This is the exception. Pseudomembranous colitis is caused by toxins A and B of Clostridioides difficile, which glucosylate Rho GTPases and disrupt the actin cytoskeleton of the colonic epithelium; phospholipase A is not involved. The other three are correct: the organism is carried asymptomatically in the gut of a proportion of healthy people, the disease follows antibiotic disturbance of the flora, and oral vancomycin is a standard treatment.

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