Discussion
Not true about Botulinum toxin:
Answer: A
Correct answer: Increased acetylcholine release
Botulinum toxin does exactly the opposite: its light chain is a zinc protease that cleaves the SNARE proteins of vesicle fusion, so acetylcholine cannot be released at the neuromuscular junction and flaccid paralysis follows. That is why it treats blepharospasm, dystonia and wrinkles, and why the option describing an irreversible decrease in acetylcholine is true. The block persists until new nerve terminals sprout, which is why the therapeutic effect lasts some three to four months.
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