Discussion
DNA polymerase synthesizes
Answer: A
Correct answer: DNA in 5’-3’ direction
Every known DNA polymerase adds nucleotides only to a free 3’-OH, so the new strand grows 5’→3’. The reason is chemical: the energy for the bond comes from the incoming nucleotide’s own triphosphate, so the growing end must be the one that attacks it. This one constraint is what forces the lagging strand to be made in Okazaki fragments.
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