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Eukaryotes differ from prokaryote in mechanism of DNA replication due to ____________

  • A.Use of DNA primer rather than RNA primer
  • B.Different enzyme for synthesis of lagging and leading strand
  • C.Discontinuous rather than semi-discontinuous replication
  • D.Unidirectional rather than semi-discontinuous replication

Answer: C

Correct answer: Different enzyme for synthesis of lagging and leading strand

In eukaryotes the two strands are made by different polymerases - Pol ε on the leading strand and Pol δ on the lagging strand, with Pol α/primase laying down the primers. In E. coli a single Pol III holoenzyme handles both. The other options are false: eukaryotes also use RNA primers, and their replication is semi-discontinuous and bidirectional, just as in bacteria.

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