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What is the origin of replication?

  • A.Particular site at which DNA replication starts
  • B.Site which prevents initiation
  • C.Random location on the DNA
  • D.Site at which replication terminated

Answer: A

Correct answer: Particular site at which DNA replication starts

The origin is a defined sequence at which the initiator protein binds and the duplex is first opened - oriC in E. coli. It is not a random point: the site is AT-rich, so it takes less energy to melt, and it carries the repeats the initiator recognises.

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