Discussion
What is the only common methylation in the DNA of eukaryotes?
Answer: C
Correct answer: Cytosine in CpG dinucleotides
The one common modification in eukaryotic DNA is 5-methylcytosine, and it occurs almost entirely at cytosines followed immediately by a guanine - the CpG dinucleotide. Because the pattern is symmetrical on the two strands, it is copied faithfully after replication, which is what makes DNA methylation heritable and central to gene silencing and imprinting.
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