Discussion
Enzyme, responsible for proofreading base pairing is
Answer: A
Correct answer: DNA polymerase
DNA polymerase proofreads with its own 3’→5’ exonuclease: a mispaired base distorts the active site, the enzyme backs up, excises the wrong nucleotide and tries again. This raises fidelity by roughly a hundredfold over base pairing alone.
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