Discussion
The rapid appearance of HIV-1 strains that are resistant to AIDS drugs is due in part to which of the following property of its reverse transcriptase?
Answer: C
Correct answer: It lacks a proofreading exonuclease
HIV-1 reverse transcriptase has no 3’→5’ exonuclease, so a misincorporated base is never corrected. The resulting error rate - roughly one per genome per replication cycle - means an infected person carries a swarm of variants, and any drug-resistant one already present is simply selected for as soon as the drug is applied. Combination therapy is the answer, since resistance to three drugs at once is far less likely.
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