Discussion
The packing ratio of nucleosomes is about
Answer: B
Correct answer: 7
Wrapping about 147 base pairs of DNA - some 50 nm of contour length - around a histone octamer roughly 7 nm across compresses it by a factor of about 6-7. That is only the first level of packing; the 30 nm fibre, loops and higher-order folding together achieve some 10,000-fold compaction in a metaphase chromosome.
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