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Nucleosome is

  • A.an octamer of four histones with H1 protein
  • B.an hexamer of three histones with H1 protein
  • C.an hexamer of three histones without H1 protein
  • D.an octamer of four histones without H1 protein

Answer: D

Correct answer: an octamer of four histones without H1 protein

The nucleosome core particle is an octamer made of two copies each of the four core histones H2A, H2B, H3 and H4, with about 147 bp of DNA around it. H1 is not part of it: it binds outside, at the point where the DNA enters and leaves, and is called the linker histone for that reason.

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