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The lagging strand of DNA is replicated in short pieces because :

  • A.Of limitation of space
  • B.Otherwise the helix will become distorted
  • C.DNA polymerase can synthesize in one direction only
  • D.To make proof-reading of code easier

Answer: C

The lagging strand is made in pieces because DNA polymerase can synthesize in one direction only.

DNA polymerase adds nucleotides only to a free 3'-OH, so it synthesises new DNA in the 5' to 3' direction. The two template strands are antiparallel, so as the fork opens one new strand (the leading strand) can be extended continuously towards the fork, while the other must be made backwards, away from the fork, in short Okazaki fragments, each started from a new RNA primer and later joined by ligase.

Space, distortion of the helix and ease of proof-reading are not the reason; the cause is the fixed direction of polymerase.

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