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A signal sequence on a newly made protein determines that the protein will

  • A.be exported from the cell without modification
  • B.be directed into the endoplasmic reticulum
  • C.be broken down immediately by cytosolic proteases
  • D.remain permanently inside the cell nucleus

Answer: B

The short stretch of amino acids is recognised as the chain emerges from the ribosome and the whole assembly is docked at the reticulum. It is usually cut off once the protein is inside the lumen. The mature protein therefore carries no trace of the address that delivered it.

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