Discussion
Lysosomes are formed by budding from the
Answer: A
Correct answer: trans Golgi network
Lysosomal hydrolases are tagged in the cis Golgi with mannose 6-phosphate, recognised by receptors at the trans Golgi network, and packaged into vesicles that bud from it. The tag is the address label: a defect in the enzyme that applies it sends the hydrolases out of the cell instead, which is the basis of I-cell disease.
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