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A protein that is to remain in the endoplasmic reticulum typically carries

  • A.no targeting signal sequence of any kind at all
  • B.a mannose-6-phosphate tag added in the Golgi
  • C.a hydrophobic anchor holding it in the membrane
  • D.a short retrieval sequence at its end

Answer: D

The KDEL sequence is recognised by a receptor in the Golgi, which packages the protein into a retrograde vesicle and returns it. Without such a signal it would be carried forward with the cargo. Bulk flow is the default, and staying put is what requires a signal.

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