Discussion
Which of the following takes place due to phosphorylation of isocitrate dehydrogenase?
Answer: A
Correct answer: Inhibits the binding of isocitrate at active site
Phosphorylation of isocitrate dehydrogenase adds a bulky negative phosphate group at the active site, which repels the negatively charged substrate and prevents isocitrate from binding. The enzyme is not degraded, and the change is reversed by a phosphatase - the switch that sends isocitrate into the glyoxylate cycle instead of the TCA cycle.
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