Discussion
The “lock and key” theory of enzyme action was put forward by
Answer: B
Correct answer: Fischer
Emil Fischer proposed the lock-and-key model in 1894: the substrate fits the active site as a key fits a lock, which explains an enzyme’s specificity. Koshland later refined it into the induced-fit model, in which the site adjusts its shape as the substrate binds - a better account of what actually happens.
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