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Reversible covalent modification involves

  • A.Activation of proenzymes
  • B.Inhibition of proenzymes
  • C.Denaturation of proenzymes
  • D.None of the above

Answer: A

Correct answer: Activation of proenzymes

Reversible covalent modification - phosphorylation above all - switches enzymes on and off by attaching and removing a group. Many proenzymes are activated in this way, and the modification can be undone by the opposing enzyme, a phosphatase. (Activation by cleavage, as with pepsinogen, is the irreversible kind.)

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