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The phenotypic ratio obtained in F2 is 2 : 1 in the progeny of cross due to presence of :

  • A.Dominant allele
  • B.Recessive allele
  • C.Lethal allele
  • D.Co-dominant allele

Answer: C

A 2 : 1 ratio is due to a lethal allele.

Crossing two heterozygotes normally gives 1 AA : 2 Aa : 1 aa. If the allele is lethal when homozygous, one class dies before it can be counted, and the survivors appear in a 2 : 1 ratio. The classic case is the yellow coat allele AY in mice (Cuenot): yellow x yellow gives 2 yellow : 1 non-yellow, because AYAY embryos die.

A plain dominant allele gives 3 : 1, a recessive one also 3 : 1, and a co-dominant (or incompletely dominant) one 1 : 2 : 1. Only lethality removes a class and leaves 2 : 1.

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