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Precolumn used for the conditioning of mobile phase is known as :

  • A.Guard column
  • B.Scavenger column
  • C.Conditioning column
  • D.Mobilizing column

Answer: B

The precolumn is a scavenger column.

In HPLC a scavenger (or saturator) column is placed between the pump and the injector. It is packed with silica, which dissolves slightly into the mobile phase, so the mobile phase is conditioned (pre-saturated) before it reaches the analytical column and does not dissolve that column's packing.

A guard column sits after the injector, just before the analytical column, and protects it by trapping particles and strongly retained sample components; it does not condition the mobile phase. 'Conditioning column' and 'mobilizing column' are not standard terms.

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