Discussion
Which one of the following compounds is NOT a translation inhibitor?
Answer: D
The compound that is not a translation inhibitor is rifampicin.
Rifampicin binds the β subunit of bacterial RNA polymerase and blocks transcription, the step before translation, which is why it is used against Mycobacterium tuberculosis.
The other three act on the ribosome. Chloramphenicol binds the 50S subunit and inhibits peptidyl transferase. Cycloheximide blocks translocation on eukaryotic 80S ribosomes. Puromycin mimics the 3′ end of an aminoacyl-tRNA, is joined to the growing chain and causes its premature release.
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