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Which is the right sequence of stages of Haemostasis?

  • A.Vasoconstriction → Coagulation → Platelet plug formation → Fibrinolysis
  • B.Fibrinolysis → Vasoconstriction → Coagulation → Platelet plug formation
  • C.Vasoconstriction → Platelet plug formation → Coagulation → Fibrinolysis
  • D.Platelet plug formation → Fibrinolysis → Coagulation → Vasoconstriction

Answer: C

The right sequence is Vasoconstriction → Platelet plug formation → Coagulation → Fibrinolysis.

When a vessel is injured it first constricts to reduce blood flow. Platelets then stick to the exposed collagen and to each other, forming a temporary plug. The clotting cascade converts fibrinogen into fibrin, which reinforces the plug into a stable clot. Finally, once the vessel heals, fibrinolysis dissolves the clot.

The other options put coagulation before the platelet plug, or fibrinolysis first, which would dissolve a clot that has not yet formed.

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