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Discussion

Antibody to hepatitis B surface antigen in the absence of any other marker indicates

  • A.an infection acquired within the last week
  • B.immunity from vaccination
  • C.acute infection in its early stage
  • D.chronic infection with active replication

Answer: B

The vaccine contains only the surface antigen, so it raises anti-HBs alone. Recovery from natural infection leaves anti-HBs together with antibody to the core antigen, and that core antibody is the marker that separates the two.

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