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Which marker distinguishes immunity from natural infection from immunity from vaccination?

  • A.The surface antigen itself
  • B.The e antigen in serum
  • C.Antibody to the core antigen
  • D.Antibody to the surface antigen

Answer: C

Correct answer: Antibody to the core antigen

The vaccine contains only the surface antigen, so it raises antibody to that and to nothing else. Natural infection exposes the immune system to the whole virus, including the core, so anti-HBc is present. Its presence therefore marks past infection, and its absence in a person with surface antibody marks vaccination.

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