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The window period in hepatitis B serology is the interval when

  • A.the virus is present but causes no liver damage
  • B.surface antigen has gone but its antibody has not yet appeared
  • C.no marker of any kind can be detected in serum
  • D.the e antigen is present without the surface antigen

Answer: B

Between the disappearance of the surface antigen and the appearance of its antibody, core antibody is the only positive marker, so testing for surface antigen and its antibody alone can wrongly suggest no infection. Including anti-HBc is what closes the gap.

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