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Hepatitis D virus is described as defective because it

  • A.is unable to enter a liver cell unaided
  • B.requires hepatitis B surface antigen for its coat
  • C.cannot replicate its own nucleic acid at all
  • D.lacks any nucleic acid of its own

Answer: B

The delta agent encodes its own antigen and a small circular RNA genome but no envelope protein, so it can only be packaged and transmitted using the surface antigen of hepatitis B. Without that helper it cannot complete a cycle.

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