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Discussion

Hemophilia and colour blindness are :

  • A.Autosomal dominant inheritance patterns
  • B.Y-linked recessive inheritance
  • C.X-linked recessive inheritance
  • D.Y- and X-linked dominant inheritance respectively

Answer: C

Both are X-linked recessive inheritance.

The genes for clotting factor VIII (haemophilia A) and for the red and green opsins (red-green colour blindness) lie on the X chromosome, and the disease alleles are recessive. A male, with one X, shows the trait whenever he inherits the allele; a female is usually an unaffected carrier. So these conditions are far more common in men and pass from carrier mothers to sons.

They are not autosomal, since their genes are on the X, and they are not Y-linked; the Y carries very few genes and Y-linked traits would pass only from father to son. Neither is dominant.

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