Discussion
Proenzyme pepsinogen is secreted from 'P' of gastric mucosa and converted into active enzyme pepsin on exposure to 'Q' secreted from 'R'. Choose the CORRECT combination of P, Q and R.
Answer: A
The correct combination is P - chief cells, Q - hydrochloric acid, R - oxyntic cells.
Pepsinogen is secreted by the chief (peptic) cells of the gastric glands. Hydrochloric acid, secreted by the oxyntic (parietal) cells, lowers the pH and converts pepsinogen into active pepsin, which then activates more pepsinogen itself.
Parietal and oxyntic cells are the same cells and secrete HCl, not pepsinogen, so the options naming them as P are wrong. Enterokinase acts in the small intestine, on trypsinogen. Gastrin is a hormone that stimulates acid secretion; it does not itself activate pepsinogen and is made by G cells, not oxyntic cells.
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