Discussion
A rare disease congenital agammaglobulinemia is caused due to abnormality in __________________
Answer: A
Correct answer: humoral antibody
Congenital agammaglobulinaemia - Bruton’s disease - is a failure of B cells to mature, so almost no immunoglobulin is made. The defect is therefore in the humoral (antibody) arm. Cell-mediated immunity is intact, which is why such patients handle viruses reasonably well but suffer repeated bacterial infections, the very ones antibody normally controls.
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