Discussion
Which of the following enzymes is not a part of fatty acid synthetase complex ?
Answer: B
The enzyme not in the fatty acid synthase complex is β-hydroxy acyl CoA dehydrogenase.
That enzyme belongs to β-oxidation, the breakdown of fatty acids in mitochondria, where it oxidises the β-hydroxy group using NAD+. The synthase runs the reverse sequence with different enzymes: condensation, then reduction of the β-keto group (β-ketoacyl reductase), dehydration (β-hydroxyacyl dehydratase) and a second reduction (enoyl reductase).
Enoyl reductase, β-keto acyl reductase and acetyl transacylase are all activities of the synthase complex, so they are the distractors.
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