Discussion
What does end-capping a column achieve?
Answer: B
A short silane such as trimethylsilyl reaches silanols that the bulky octadecyl chain could not, reducing the tailing of basic compounds substantially. It has nothing to do with the column's physical ends, adds no second phase, and does not alter the pores. Treating the residue of an incomplete reaction with a smaller reagent is a neat chemical solution to a chromatographic problem. Naming the cost of a choice alongside its benefit is what turns a fact into a design decision.
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