Discussion
Why is a hybrid or polymer-coated particle sometimes used?
Answer: C
Incorporating organic groups into the particle extends the usable pH from roughly two to eight up to one to twelve, which allows basic compounds to be run in their neutral form. Such particles cost more, give comparable pressure, and still carry a bonded phase. Extending the pH range matters because ionisation state controls retention so strongly, and being confined to a narrow window forces compromises elsewhere. Checking the units of each quantity catches a wrong formula before the arithmetic begins.
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