Discussion
Why does pH matter so much in reversed phase work?
Answer: D
A basic compound protonated at low pH becomes charged, far more soluble in the aqueous eluent, and elutes much earlier than its neutral form. The phase dissolves only outside its rated range, detectors are largely indifferent, and pumps handle acids routinely. Because retention can change several-fold across one pH unit near a compound's pKa, buffering the eluent is essential rather than optional. Reading the definition literally, rather than recalling a formula, is the reliable route through questions of this shape.
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