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Why does an isotopically labelled standard correct ion suppression?

  • A.It elutes well away from the suppressing region
  • B.It prevents the matrix from reaching the source
  • C.It co-elutes and is suppressed equally
  • D.It ionises far more efficiently than the analyte

Answer: C

A labelled analogue elutes at essentially the same time and experiences exactly the same suppression, so the ratio of the two signals is unaffected. Eluting elsewhere would defeat the purpose, higher efficiency is not wanted, and nothing is kept out of the source. Having a companion that shares the analyte's fate in every respect except mass is what makes the correction exact rather than approximate. The shared properties explain why these belong to one family, and the differences explain why more than one exists.

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