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What does robustness testing examine?

  • A.Tolerance to small deliberate changes in conditions
  • B.Performance at the limits of the calibration range
  • C.Agreement between two different analysts
  • D.Stability of the sample during storage

Answer: A

Varying the pH, the organic content, the flow and the temperature slightly shows whether the method survives the ordinary variation of routine use. Range, intermediate precision and stability are separate parameters. A method that only works when every condition is exact will fail somewhere else, so deliberately disturbing it before release is what predicts whether it will transfer.

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