Discussion
A peak tails badly for a basic compound. What should be tried first?
Answer: B
Silanol interaction is the usual cause, and protonating the silanols at low pH or using a column with fewer of them addresses it directly. Flow, injection volume and detector settings change other things. Because the mechanism is chemical rather than physical, the remedy must be chemical too, which is why altering the eluent or the column is tried before anything else.
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