Discussion
Retention times shorten gradually over many injections. What should be suspected?
Answer: D
Hydrolysis at low pH or dissolution at high strips bonded chains from the silica, so there is less stationary phase and everything elutes sooner. A leak would lengthen retention by reducing flow, detector drift affects response, and concentration does not shift retention. Because the change is irreversible, recognising it early is what prompts a review of the eluent's pH before the next column goes the same way. A single measurement chosen to respond to the one asymmetry beats several that respond to shared behaviour.
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